Medical Technology for Health (MTH) https://heika-research.de/en/research/medical-technology-health-mth en Improved Phenotyping of Cardiomypathy Patients by Means of Imaging-Driven Computational Modeling of Cardiac Biomechanics https://heika-research.de/en/research/medical-technology-health-mth/improved-phenotyping-cardiomypathy-patients-means-imaging <span class="field field--name-title field--type-string field--label-hidden">Improved Phenotyping of Cardiomypathy Patients by Means of Imaging-Driven Computational Modeling of Cardiac Biomechanics</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/en/user/31" typeof="schema:Person" property="schema:name" datatype="" content="Maria Garcia Hernandez">Maria Garcia H…</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 08/30/2018 - 13:29</span> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p>In this project, we will combine clinical cardiovascular magnetic resonance imaging (CMR) with computational modelling of cardiac biomechanics in order to improve diagnosis of cardiomyopathy. Different kinds of cardiomyopathy cannot be sufficiently differentiated with currently available diagnostic tools, which hinders optimal treatment tailoring. The dynamics of the contraction of the heart are driven by the interplay of the active tension developed by the heart muscle cells and the passive mechanical properties of the cardiac tissue. Despite considerable advances in CMR techniques, the spatiotemporal distribution of active tension and most of the tissue properties cannot be imaged in vivo today. However, these measures could be of great value to address the challenge of phenotyping different kinds of cardiomyopathy to optimally tailor therapy for individual patients.<br /> Therefore, we will develop a method to estimate active and passive mechanical properties of the individual patient by combining cutting edge imaging data with a computational model of cardiac elastomechanics. In detail, we will solve the ‘inverse problem of cardiac mechanics’ and demonstrate for the first time the feasibility using actual imaging data.<br /> The expertise of the Cardiac Imaging Group at University Hospital Heidelberg and the Institute of Biomedical Engineering at Karlsruhe Institute of Technology (KIT), both partners with a track-record of scientific excellence and high innovation potential, will be combined within the HEiKA Research Bridge “Medical Technology for Health”. By synergistically joining forces, we will deliver a proof of concept for a highly innovative diagnostic tool, allowing to optimally phenotype cardiomyopathy patients based on non-invasive CMR measurements. The demonstrated feasibility will form the basis of a follow-up grant proposal for third-party funding ensuring sustainable use of the initial HEiKA funding and the research results as well as continuance of the project. </p></div> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Research bridges</div> <div class="field__items"> <div class="field__item"><a href="/en/research/medical-technology-health-mth" hreflang="en">Medical Technology for Health (MTH)</a></div> </div> </div> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <time datetime="2018-01-01T12:00:00Z" class="datetime">01/01/2018</time> </div> </div> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"><time datetime="2018-12-31T12:00:00Z" class="datetime">12/31/2018</time> </div> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <article data-history-node-id="116" role="article" about="/index.php/en/prof-dr-med-matthias-friedrich" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/prof-dr-med-matthias-friedrich" rel="bookmark"><span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. med. Matthias Friedrich</span> </a> </h2> </div> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Cardiovascular Imaging Research</div> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Heidelberg University Hospital</div> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.klinikum.uni-heidelberg.de/index.php?id=140715&amp;L=0">Matthias Friedrich</a></div> </div> </div> </article> <article data-history-node-id="117" role="article" about="/index.php/en/prof-dr-rer-nat-olaf-dossel" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/index.php/en/prof-dr-rer-nat-olaf-dossel" rel="bookmark"><span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. rer. nat. Olaf Dössel</span> </a> </h2> </div> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute of Biomedical Engineering</div> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technology</div> </div> </div> </article> </div> </div> Thu, 30 Aug 2018 11:29:57 +0000 Maria Garcia Hernandez 134 at https://heika-research.de Invasions- und Genexpressionsanalysen im Urothelkarzinom der Harnblase: Entwicklung eines mikrofluidischen in vitro Lymphgefäßmodells https://heika-research.de/en/research/medical-technology-health-mth/invasions-und-genexpressionsanalysen-im-urothelkarzinom-der <span class="field field--name-title field--type-string field--label-hidden">Invasions- und Genexpressionsanalysen im Urothelkarzinom der Harnblase: Entwicklung eines mikrofluidischen in vitro Lymphgefäßmodells</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/en/user/31" typeof="schema:Person" property="schema:name" datatype="" content="Maria Garcia Hernandez">Maria Garcia H…</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 08/30/2018 - 13:42</span> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p>Das Urothelkarzinom der Blase zählt zu der häufigsten Krebserkrankung weltweit und weist eine hohe Morbidität bzw. Mortalität auf. Ein wichtiger Faktor bei der Progression im Urothelkarzinom der Blase ist die Lymphgefäßinvasion. Die molekularen Mechanismen, die bei der Progression und Invasion des Urothelkarzinoms der Blase eine Rolle spielen, sind nicht vollständig geklärt. Derartige molekulare und zelluläre Untersuchungen sind auf Grund der limitierten in vivo und in vitro Modelle eingeschränkt möglich. Im Rahmen dieses Projekts wird ein mikrofluidisches Gefäßsystem als artifizielles Modell der Mikrozirkulation und Zellinteraktion im Lymphknoten etabliert. Der geplante Aufbau eröffnet (1) die Möglichkeit für Wachstums- und Migrationsanalysen von Tumorzellen im Urothelkarzinom durch Implementierung ortsaufgelöster Impedanzsensorik, (2) die Analyse von Zell-Zell- Interaktionen im Mikroenvironment, (3) die Unterschiede unter fließenden und statischen Bedingungen zu analysieren und zu vergleichen und (4) die Untersuchung der Dynamik von Genexpressionsmustern bedingt durch die Invasion von Tumorzellen. </p></div> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Research bridges</div> <div class="field__items"> <div class="field__item"><a href="/en/research/medical-technology-health-mth" hreflang="en">Medical Technology for Health (MTH)</a></div> </div> </div> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <time datetime="2018-01-01T12:00:00Z" class="datetime">01/01/2018</time> </div> </div> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"><time datetime="2018-12-31T12:00:00Z" class="datetime">12/31/2018</time> </div> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <article data-history-node-id="118" role="article" about="/en/pd-dr-med-philipp-erben" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/en/pd-dr-med-philipp-erben" rel="bookmark"><span class="field field--name-title field--type-string field--label-hidden">PD Dr. med. Philipp Erben</span> </a> </h2> </div> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Medical Faculty Mannheim</div> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">University of Heidelberg</div> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.umm.uni-heidelberg.de/forschung/forschungsschwerpunkte/onkologie/mitglieder/pd-dr-philipp-erben/">Philipp Erben</a></div> </div> </div> </article> <article data-history-node-id="119" role="article" about="/en/prof-dr-andreas-guber" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/en/prof-dr-andreas-guber" rel="bookmark"><span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Andreas Guber</span> </a> </h2> </div> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute of Microstructure Technology</div> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technology</div> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.imt.kit.edu/1443_1488.php">Andreas Guber</a></div> </div> </div> </article> </div> </div> Thu, 30 Aug 2018 11:42:51 +0000 Maria Garcia Hernandez 135 at https://heika-research.de 3D gedruckte Nano-Zellgerüstträger für die in situ Knorpelregeneration zur Behandlung von Gelenkknorpelschäden. Untersuchungen zum Zellrecruitment in einem Bioreaktor. https://heika-research.de/en/research/medical-technology-health-mth/3d-gedruckte-nano-zellgerusttrager-fur-die-situ <span class="field field--name-title field--type-string field--label-hidden">3D gedruckte Nano-Zellgerüstträger für die in situ Knorpelregeneration zur Behandlung von Gelenkknorpelschäden. Untersuchungen zum Zellrecruitment in einem Bioreaktor.</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span lang="" about="/en/user/32" typeof="schema:Person" property="schema:name" datatype="">Regine Kleber</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 11/12/2018 - 17:10</span> <div class="clearfix text-formatted field field--name-field-summary field--type-text-long field--label-hidden field__item"><p><span><span><span><span><span>Im Rahmen des Projektes sollen künstliche Zellgerüstträger zur in situ Regeneration von hyalinem Knorpel zur Behandlung von Knorpelschäden mittels Nano 3D-Druck hergestellt werden. Durch den Einsatz der sog. „Zwei Photonen Lithographie“ (Nanoscribe) wird es möglich, im Nanometermaßstab genaue Zellgerüste additiv herzustellen. Durch solch einen additiven und hochpräzisen Aufbau der Zellgerüste sind komplexe Strukturen realisierbar, mit denen die anspruchsvollen mechanischen Eigenschaften von natürlichem hyalinem Knorpel realisiert werden können. Diese 3D Scaffolds sollen dabei als Gerüst für Stammzellen und anderen Zellen dienen und diesen ermöglichen, neue extrazelluläre Matrix zu produzieren und im Idealfall wieder gesundes hyalines Knorpelgewebe auszubilden.</span></span></span></span></span></p> <p><span><span><span><span><span>Zuerst werden Vorversuche mit starren Scaffolds durchgeführt. Hierbei sollen zunächst optimale Parameter, wie z.B. Porengröße, Oberflächenqualität usw. sowie deren Einfluss auf die Besiedelung der Scaffolds durch verschiedene Zelltypen (z.B. Chondrosarcomzelllinie, Stammzellen) identifiziert werden.</span></span></span></span></span></p> <p><span><span><span><span><span>Auf diesen Ergebnissen und auf KIT-Seite durchgeführten mechanischen Simulationen basierend werden elastisch verformbare Zellgerüstträger konstruiert und mittels 3D Druck hergestellt, die die mechanischen Eigenschaften des hyalinen Knorpels möglichst gut nachbilden sollen. Diese elastischen Scaffolds werden in einem Bioreaktor kontinuierlich mechanisch belastet und anschließend untersucht, ob unter den verwendeten Parametern ein erfolgreiches Zellrecruitment von Stammzellen aus einem unteren Reservoir des Bioreaktors in das daraufliegende Scaffold stattfindet. Dieser wichtige und entscheidende Vorgang wäre der Ausgangspunkt für eine in situ Regeneration von Knorpelgewebe, der den klinischen Gegebenheiten bei einer sog. Matrix assoziierten Chondrogenese (AMIC®) nahe kommt.</span></span></span></span></span></p> <p> </p></div> <div class="field field--name-field-research-bridges field--type-entity-reference field--label-above"> <div class="field__label">Research bridges</div> <div class="field__items"> <div class="field__item"><a href="/en/research/medical-technology-health-mth" hreflang="en">Medical Technology for Health (MTH)</a></div> </div> </div> <div class="field field--name-field-start-date field--type-datetime field--label-above"> <div class="field__label">Start date</div> <div class="field__item"> <time datetime="2019-01-01T12:00:00Z" class="datetime">01/01/2019</time> </div> </div> <div class="field field--name-field-end-date field--type-datetime field--label-hidden field__item"><time datetime="2019-12-31T12:00:00Z" class="datetime">12/31/2019</time> </div> <div class="field field--name-field-contact-person field--type-entity-reference field--label-above"> <div class="field__label"><h3>Project management</h3></div> <div class="field__items"> <article data-history-node-id="197" role="article" about="/en/prof-dr-markus-schwarz" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/en/prof-dr-markus-schwarz" rel="bookmark"><span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Markus Schwarz</span> </a> </h2> </div> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Medical Faculty Mannheim / Experimental Orthopedics and Trauma Surgery </div> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Heidelberg University</div> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://w2.umm.de/ouz-orthopaedie-mannheim/forschung-lehre/experimentelle-orthopaedie-und-unfallchirurgie/">Research Group Schwarz</a></div> </div> </div> </article> <article data-history-node-id="119" role="article" about="/en/prof-dr-andreas-guber" class="node node--type-people-profile node--view-mode-teaser"> <div class="node__content"> <div class="content-container"> <div class="header-container"> <h2> <a href="/en/prof-dr-andreas-guber" rel="bookmark"><span class="field field--name-title field--type-string field--label-hidden">Prof. Dr. Andreas Guber</span> </a> </h2> </div> <div class="field field--name-field-institute field--type-string field--label-hidden field__item">Institute of Microstructure Technology</div> <div class="field field--name-field-facility field--type-string field--label-hidden field__item">Karlsruhe Institute of Technology</div> <div class="field field--name-field-link field--type-link field--label-hidden field__item"><a href="https://www.imt.kit.edu/1443_1488.php">Andreas Guber</a></div> </div> </div> </article> </div> </div> Mon, 12 Nov 2018 16:10:56 +0000 Regine Kleber 210 at https://heika-research.de